Glycolate and oxalate are the metabolic by-products primarily responsible for the metabolic acidosis and renal damage seen in ethylene glycol toxicosis. Alcohol dehydrogenase also catalyzes the initial steps in the metabolism of ethylene glycol and methanol to their toxic metabolites.Įthylene glycol, the main component of most antifreezes and coolants, is metabolized to glycoaldehyde, which undergoes subsequent sequential oxidations to yield glycolate, glyoxylate, and oxalate. Alcohol dehydrogenase catalyzes the oxidation of ethanol to acetaldehyde. Fomepizole is dialyzable and should be given q4h during hemodialysis.Īntizol (fomepizole) is a competitive inhibitor of alcohol dehydrogenase. Solutions showing haziness, particulate matter, precipitate, discoloration, or leakage should not be used.ĭosing: loading dose: 15 mg/kg, followed by 10 mg/kg q12h x 4 doses, then 15 mg/kg q12h thereafter until ethylene glycol levels 50 mg/dl. Store at controlled room temperature, 20° to 25° C (68° to 77° F) Therefore, maintain sterile conditions, and after dilution do not use beyond 24 hours. Stability: Antizol® diluted in 0.9% sodium chloride injection or dextrose 5% injection remains stable and sterile for at least 24 hours when stored refrigerated or at room temperature.

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